Genetics of atrial fibrillation.

ABSTRACT:

Purpose of review

Atrial fibrillation is the most common sustained cardiac arrhythmia. In addition to traditional risk factors, it is increasingly recognized that a genetic component underlies atrial fibrillation development. This review aims to provide an overview of the genetic cause of atrial fibrillation and clinical applications, with a focus on recent developments.

Recent findings

Genome-wide association studies have now identified around 140 genetic loci associated with atrial fibrillation. Studies into the effects of several loci and their tentative gene targets have identified novel pathways associated with atrial fibrillation development. However, further validations of causality are still needed for many implicated genes. Genetic variants at identified loci also h

SUBMITTER: Kim JA 

PROVIDER: S-EPMC8211390 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature