A 29-mRNA host response test from blood accurately distinguishes bacterial and viral infections among emergency department patients.

ABSTRACT:

Background

Whether or not to administer antibiotics is a common and challenging clinical decision in patients with suspected infections presenting to the emergency department (ED). We prospectively validate InSep, a 29-mRNA blood-based host response test for the prediction of bacterial and viral infections.

Methods

The PROMPT trial is a prospective, non-interventional, multi-center clinical study that enrolled 397 adult patients presenting to the ED with signs of acute infection and at least one vital sign change. The infection status was adjudicated using chart review (including a syndromic molecular respiratory panel, procalcitonin and C-reactive protein) by three infectious disease physicians blinded to InSep results. InSep (version BVN-2) was performed using PAXgene Bloo

SUBMITTER: Safarika A 

PROVIDER: S-EPMC8211458 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature