Unique Biomarker Characteristics in Gestational Diabetes Mellitus Identified by LC-MS-Based Metabolic Profiling.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is a type of glucose intolerance disorder that first occurs during women's pregnancy. The main diagnostic method for GDM is based on the midpregnancy oral glucose tolerance test. The rise of metabolomics has expanded the opportunity to better identify early diagnostic biomarkers and explore possible pathogenesis.

Methods

We collected blood serum from 34 GDM patients and 34 normal controls for a LC-MS-based metabolomics study.

Results

184 metabolites were increased and 86 metabolites were decreased in the positive ion mode, and 65 metabolites were increased and 71 were decreased in the negative ion mode. Also, it was found that the unsaturated fatty acid metabolism was disordered in GDM. Ten metabolites with the most signi

SUBMITTER: Meng X 

PROVIDER: S-EPMC8211500 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature