MXRA5 Is a Novel Immune-Related Biomarker That Predicts Poor Prognosis in Glioma.

ABSTRACT:

Background

Glioma is the most common primary intracranial tumor and is associated with poor prognosis. Identifying effective biomarkers for glioma is particularly important. MXRA5, a secreted glycoprotein, is involved in cell adhesion and extracellular matrix remodeling and has been reported to be expressed in many cancers. However, the role and mechanism of action of MXRA5 in gliomas remain unclear. This study was aimed at investigating the role of MXRA5 at the transcriptome level and its clinical prognostic value.

Methods

In this study, RNA microarray data of 301 glioma patients from the Chinese Glioma Genome Atlas (CGGA) were collected as a training cohort and RNA-seq data of 702 glioma samples from The Cancer Genome Atlas (TCGA) were used for validation. We analyzed the

SUBMITTER: Sun JZ 

PROVIDER: S-EPMC8211501 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature