Altered Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia.

ABSTRACT:

Background

The molecular mechanism of nonobstructive azoospermia (NOA) remains unclear. The aim of this study was to identify gene expression changes in NOA patients and to explore potential biomarkers and therapeutic targets.

Methods

The gene expression profiles of GSE45885 and GSE145467 were collected from the Gene Expression Omnibus (GEO) database, and the differences between NOA and normal spermatogenesis were analyzed. Enrichment analysis was performed to explore biological functions for common differentially expressed genes (DEGs) in GSE45885 and GSE145467. Coexpression analysis of DEGs in GSE45885 was performed, and two modules with the highest correlation with NOA were screened. Key genes were then screened from the intersection genes of the two modules and common DE

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8211532 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature