Nuclear scaffold protein p54^nrb/NONO facilitates the hypoxia-enhanced progression of hepatocellular carcinoma.

ABSTRACT: Hypoxia and related oxidative stress are closely related to the development and treatment of hepatocellular carcinoma (HCC). However, the mechanism mediated by hypoxia in HCC has not yet been elucidated. Here, we found multifunction scaffold protein p54^nrb/NONO exerted pleiotropic effects to regulate hypoxia transcription signals, thereby enhancing the progression of liver cancer. Extensive analysis of clinical data demonstrated that NONO was significantly upregulated and represented as a poor prognostic indicator of HCC. The crucial role of NONO in driving angiogenesis and glycolysis, two well-known cancer phenotypes mediated by hypoxia, was examined in vitro an in vivo. Mechanistically, NONO interacted with and stabilized both HIF-1 and HIF-2 complexes thus activating the tran

SUBMITTER: Shen M 

PROVIDER: S-EPMC8211563 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature