A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.

ABSTRACT: Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain unknown in humans. Here we characterise key events of human embryo morphogenesis, in the period between implantation and gastrulation, using single-cell analyses and functional studies. First, the embryonic epiblast cells transition through different pluripotent states and act as a source of FGF signals that ensure proliferation of both embryonic and extra-embryonic tissues. In a subset of embryos, we identify a group of asymmetrically positioned extra-embryonic hypoblast cells expressing inhibitors of BMP, NODAL and WNT signalling pathways. We suggest that this group of cells ca

SUBMITTER: Mole MA 

PROVIDER: S-EPMC8211662 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature