Unknown

Dataset Information

0

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.

ABSTRACT: Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding of the genetic landscape and biology of PTCL-NOS, we perform RNA-sequencing of 18 cases and validate results in an independent cohort of 37 PTCL cases. We identify FYN-TRAF3IP2, KHDRBS1-LCK and SIN3A-FOXO1 as new in-frame fusion transcripts, with FYN-TRAF3IP2 as a recurrent fusion detected in 8 of 55 cases. Using ex vivo and in vivo experiments, we demonstrate that FYN-TRAF3IP2 and KHDRBS1-LCK activate signaling pathways downstream of the T cell receptor (TCR) complex and confer therapeutic vulnerability to clinically available drugs.

SUBMITTER: Debackere K 

PROVIDER: S-EPMC8211700 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding of the genetic landscape and biology of PTCL-NOS, we perform RNA-sequencing of 18 cases and validate results in an independent cohort of 37 PTCL cases. We identify FYN-TRAF3IP2, KHDRBS1-LCK and SIN3A-FOXO1 as new in-frame fusion transcripts, with FYN  ...[more]

Similar Datasets

Transcriptomics FYN-TRAF3IP2 activating fusion oncogene in peripheral T-cell lymphoma
2020-10-01 | GSE138416 | GEO
Unknown Peripheral T-cell lymphoma, not otherwise specified- Case report.
| S-EPMC7296317 | biostudies-literature
Genomics FYN-TRAF3IP2 activating fusion oncogene in peripheral T-cell lymphoma
| PRJNA575793 | ENA
Unknown <i>FYN-TRAF3IP2</i> induces NF-κB signaling-driven peripheral T cell lymphoma.
| S-EPMC8081346 | biostudies-literature
Unknown Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified.
| S-EPMC5865443 | biostudies-literature
Unknown Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
| S-EPMC2211793 | biostudies-literature
Unknown High-grade B-cell lymphoma, not otherwise specified: a multi-institutional retrospective study.
| S-EPMC10598493 | biostudies-literature
Unknown Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified.
| S-EPMC7323262 | biostudies-literature
Unknown CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance.
| S-EPMC9975250 | biostudies-literature
Unknown Challenging our understanding of B-cell lymphomagenesis and risk: Paediatric high-grade B-cell lymphoma, not otherwise specified with a DDX3X::MLLT10 fusion and an IGH deletion.
| S-EPMC11497301 | biostudies-literature