Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface.

ABSTRACT: Calcium imaging is a powerful tool for recording from large populations of neurons in vivo. Imaging in rhesus macaque motor cortex can enable the discovery of fundamental principles of motor cortical function and can inform the design of next generation brain-computer interfaces (BCIs). Surface two-photon imaging, however, cannot presently access somatic calcium signals of neurons from all layers of macaque motor cortex due to photon scattering. Here, we demonstrate an implant and imaging system capable of chronic, motion-stabilized two-photon imaging of neuronal calcium signals from macaques engaged in a motor task. By imaging apical dendrites, we achieved optical access to large populations of deep and superficial cortical neurons across dorsal premotor (PMd) and gyral primary motor (M1)

SUBMITTER: Trautmann EM 

PROVIDER: S-EPMC8211867 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature