Association of birth mode of delivery with infant faecal microbiota, potential pathobionts, and short chain fatty acids: a longitudinal study over the first year of life.

ABSTRACT:

Objective

Caesarean section (CS) interrupts mother-to-newborn microbial transfer at birth. Beyond the neonatal period, the impact of CS on offspring gut microbiota and their short-chain fatty acids (SCFAs) remains unclear. Here, we examine birth delivery mode (CS versus vaginal delivery) with the infant gut microbiota and faecal SCFAs measured 3 and 12 months after birth.

Design

Longitudinal study.

Setting

North Carolina.

Population

In 2013-15, we enrolled pregnant women and followed up their offspring for 12 months. We asked a subset of participants, enrolled over a 3-month period, to provide faecal samples at the 3- and 12-month follow-up visits.

Methods and main outcomes

We sequenced the 16S rRNA V4 region with Illumina MiSeq and quantified SCFA conce

SUBMITTER: Mueller NT 

PROVIDER: S-EPMC8211907 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature