Blood-Based Biomarkers for Glioma in the Context of Gliomagenesis: A Systematic Review.

ABSTRACT:

Background

Gliomas are the most common and aggressive tumors of the central nervous system. A robust and widely used blood-based biomarker for glioma has not yet been identified. In recent years, a plethora of new research on blood-based biomarkers for glial tumors has been published. In this review, we question which molecules, including proteins, nucleic acids, circulating cells, and metabolomics, are most promising blood-based biomarkers for glioma diagnosis, prognosis, monitoring and other purposes, and align them to the seminal processes of cancer.

Methods

The Pubmed and Embase databases were systematically searched. Biomarkers were categorized in the identified biomolecules and biosources. Biomarker characteristics were assessed using the area under the curve (AUC), ac

SUBMITTER: Ali H 

PROVIDER: S-EPMC8211985 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature