Association between IL-18 and IL-6 gene polymorphisms and the risk of T1D in Egyptian children.

ABSTRACT:

Purpose

To test the involvement between IL-18 and IL-6 genetic polymorphisms and susceptibility to Type 1 diabetes (T1D).

Methods

Single nucleotide polymorphisms (SNPs) at positions -607A/C and - 137G/C in IL-18 promoter region were examined by sequence specific primers-polymerase chain reaction (SSP-PCR) and position -174G/C in promoter region of IL-6 gene which analyzed by Mutagenically Separated PCR (MS-PCR) in 104 T1D participants and 114 controls.

Results

IL-18 -137GC and -137CC genotypes and -137C allele were significantly decreased in T1D subjects (P < 0.05), while -137GG genotype was insignificantly increased as compared to controls. A significant decrease was detected in haplotype -137C/-607C frequency in T1D participants compared with controls

SUBMITTER: Ali YBM 

PROVIDER: S-EPMC8212230 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature