Gene set enrichment analysis of PPAR-γ regulators from Murraya odorata Blanco.

ABSTRACT:

Background

Peroxisome proliferator-activated receptor gamma (PPAR-γ) is reported to regulate insulin sensitivity and progression of Type 2 diabetes mellitus (T2DM). Hence the present study is aimed to identify PPAR-γ regulators from Murraya odorata Blanco and predict their role to manage T2DM.

Methods

Multiple in-silico tools and databases like SwissTargetPrediction, ADVERPred, PubChem, and MolSoft, were used to retrieve the information related to bioactives, targets, druglikeness character, and probable side effects as applicable. Similarly, the Kyoto Encyclopedia of Genes and Genomes (KEGG) database was used to identify the regulated pathways. Further, the bioactives-protein-pathways network interaction was constructed using Cytoscape. Finally, molecular dock

SUBMITTER: Dwivedi PS 

PROVIDER: S-EPMC8212318 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature