Fast Stereolithography Printing of Large-Scale Biocompatible Hydrogel Models.

ABSTRACT: Large size cell-laden hydrogel models hold great promise for tissue repair and organ transplantation, but their fabrication using 3D bioprinting is limited by the slow printing speed that can affect the part quality and the biological activity of the encapsulated cells. Here a fast hydrogel stereolithography printing (FLOAT) method is presented that allows the creation of a centimeter-sized, multiscale solid hydrogel model within minutes. Through precisely controlling the photopolymerization condition, low suction force-driven, high-velocity flow of the hydrogel prepolymer is established that supports the continuous replenishment of the prepolymer solution below the curing part and the nonstop part growth. The rapid printing of centimeter-sized hydrogel models using FLOAT is shown to signi

SUBMITTER: Anandakrishnan N 

PROVIDER: S-EPMC8212355 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature