Cardiac T2∗ measurement of hyperpolarized ¹³ C metabolites using metabolite-selective multi-echo spiral imaging.

ABSTRACT:

Purpose

Noninvasive imaging with hyperpolarized (HP) pyruvate can capture in vivo cardiac metabolism. For proper quantification of the metabolites and optimization of imaging parameters, understanding MR characteristics such as T2∗ s of the HP signals is critical. This study is to measure in vivo cardiac T2∗ s of HP [1-¹³ C]pyruvate and the products in rodents and humans.

Methods

A dynamic ¹³ C multi-echo spiral imaging sequence that acquires [¹³ C]bicarbonate, [1-¹³ C]lactate, and [1-¹³ C]pyruvate images in an interleaved manner was implemented for a clinical 3 Tesla system. T2∗ of each metabolite was calculated from the multi-echo images by fitting the signal decay of each region of interest mono-exponentially. The per

SUBMITTER: Ma J 

PROVIDER: S-EPMC8212421 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature