Estrogen receptor α controls metabolism in white and brown adipocytes by regulating <i>Polg1</i> and mitochondrial remodeling.

ABSTRACT: Obesity is heightened during aging, and although the estrogen receptor α (ERα) has been implicated in the prevention of obesity, its molecular actions in adipocytes remain inadequately understood. Here, we show that adipose tissue ESR1/Esr1 expression inversely associated with adiposity and positively associated with genes involved in mitochondrial metabolism and markers of metabolic health in 700 Finnish men and 100 strains of inbred mice from the UCLA Hybrid Mouse Diversity Panel. To determine the anti-obesity actions of ERα in fat, we selectively deleted Esr1 from white and brown adipocytes in mice. In white adipose tissue, Esr1 controlled oxidative metabolism by restraining the targeted elimination of mitochondria via the E3 ubiquitin ligase parkin. mtDNA content w

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC8212422 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature