Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men.

ABSTRACT:

Background

A higher intake of dietary fiber is associated with a decreased risk of chronic inflammatory diseases such as cardiovascular disease and inflammatory bowel disease. This may function in part due to abrogation of chronic systemic inflammation induced by factors such as dysbiotic gut communities. Data regarding the detailed influences of long-term and recent intake of differing dietary fiber sources on the human gut microbiome are lacking.

Methods

In a cohort of 307 generally healthy men, we examined gut microbiomes, profiled by shotgun metagenomic and metatranscriptomic sequencing, and long-term and recent dietary fiber intake in relation to plasma levels of C-reactive protein (CRP), an established biomarker for chronic inflammation. Data were analyzed using multiv

SUBMITTER: Ma W 

PROVIDER: S-EPMC8212460 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature