Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway.

ABSTRACT:

Objectives

The study of sex differences in hyperuricemia can provide not only a theoretical basis for this clinical phenomenon but also new therapeutic targets for urate-lowering therapy. In the current study, we aimed to confirm that estradiol can promote intestinal ATP binding cassette subfamily G member 2 (ABCG2) expression to increase urate excretion through the PI3K/Akt pathway.

Methods

The estradiol levels of hyperuricemia/gout patients and healthy controls were compared, and a hyperuricemia mouse model was used to observe the urate-lowering effect of estradiol and the changes in ABCG2 expression in the kidney and intestine. In vivo and in vitro intestinal urate transport models were established to verify the urate transport function regulated by estradiol. The molecul

SUBMITTER: Liu L 

PROVIDER: S-EPMC8212495 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature