The potential renal toxicity of silver nanoparticles after repeated oral exposure and its underlying mechanisms.

ABSTRACT:

Background

Silver nanoparticles (AgNPs) can accumulate in various organs after oral exposure. The main objective of the current study is to evaluate the renal toxicity induced by AgNPs after repeated oral exposure and to determine the relevant molecular mechanisms.

Methods

In this study, 40 male Wistar rats were treated with solutions containing 30, 125, 300, and 700 mg/kg of AgNPs. After 28 days of exposure, histopathological changes were assessed using hematoxylin-eosin (H&E), Masson's trichrome, and periodic acid-Schiff (PAS) staining. Apoptosis was quantified by TUNEL and immunohistochemistry of caspase-3, and the level of expression of the mRNAs of growth factors was determined using RT-PCR.

Results

Histopathologic examination revealed degenerative changes in the

SUBMITTER: Nosrati H 

PROVIDER: S-EPMC8212496 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature