Group IIA secretory phospholipase 2 independently predicts mortality and positive blood culture in emergency department sepsis patients.

ABSTRACT:

Objective

The IIA isoform of phospholipase A2 is an acute phase reactant that increases in sepsis, although data regarding its prognostic value are limited. We hypothesized that group IIA secretory phospholipase A2 (sPLA2-IIA) predicts sepsis mortality and positive cultures and sought to compare its predictive characteristics to lactate and procalcitonin.

Methods

sPLA2-IIA and procalcitonin levels were measured at enrollment in emergency department patients with early severe sepsis and compared with lactate levels. The primary outcome was in-hospital mortality. The secondary outcome was any positive culture with a sub-group analysis of only blood-culture positive patients. Optimum cut-point was determined using receiver operating characteristics curves. A multivariable model

SUBMITTER: Nandi U 

PROVIDER: S-EPMC8212558 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature