Approval success rates of drug candidates based on target, action, modality, application, and their combinations.

ABSTRACT: The current success rate of a drug candidate, from the beginning of the clinical trial to receiving marketing approval, is about 10%-20%, and it has not changed during the past few decades. Therefore, pharmaceutical companies are under pressure to select one compound, among many others, with a high probability of success. The differences in drug features affect their probabilities of approval success. In this study, we examined the approval success rates of drug candidates, developed in the United States, the European Union, or Japan, by focusing on four parameters ("drug target," "drug action," "drug modality," and "drug application") and their combinations, and identified factors that conditioned the outcome of the drug development process. We obtained a total success rate of 12.8%, afte

SUBMITTER: Yamaguchi S 

PROVIDER: S-EPMC8212735 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature