Diabetes induces myeloid bias in bone marrow progenitors associated with enhanced wound macrophage accumulation and impaired healing.

ABSTRACT: Diabetes induces dysregulation throughout the spectrum of myeloid lineage cells from progenitors to terminally differentiated cells. Another complication of diabetes is persistent inflammation, including prolonged accumulation of macrophages, which contributes to impaired wound healing. However, it remains unclear whether diabetes disrupts the response of bone marrow progenitors to peripheral injury and whether such dysregulation leads to sustained inflammation and impaired healing. Here, we demonstrated that diabetic mice (db/db, referred to here as DB) exhibit myeloid lineage bias during homeostasis and following injury. In addition, cells in the LSK (Lin^- Sca-1⁺ cKit⁺ ) population of DB mice are preprogrammed towards myeloid commitment at the transcripti

SUBMITTER: Barman PK 

PROVIDER: S-EPMC8212828 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature