Factors associated with progression to death in patients with Lassa fever in Nigeria: an observational study.

ABSTRACT:

Background

Lassa fever is endemic in several west African countries. Case-fatality rates ranging from 21% to 69% have been reported. The pathophysiology of the disease in humans and determinants of mortality remain poorly understood. We aimed to determine host protein biomarkers capable of determining disease outcome.

Methods

In this observational study, we analysed left-over blood samples from patients who tested positive for Lassa fever at Irrua Specialist Teaching Hospital, Nigeria, between January, 2014, and April, 2017. We measured viral load, concentrations of clinical chemistry parameters, and levels of 62 circulating proteins involved in inflammation, immune response, and haemostasis. Patients with a known outcome (survival or death) and at least 200 μL of good-quali

SUBMITTER: Strampe J 

PROVIDER: S-EPMC8212868 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature