Dataset Information

A rare case of giant calcified thoracic disc herniation, OPLL and OLF: how I do it.

ABSTRACT:

Background

Thoracic myelopathy can have different aetiologies. Based on the location and on the nature of spinal cord compression, different surgical approaches may be indicated.

Method

We present a rare case of thoracic myelopathy caused by the coexistence of a giant disc herniation, OPLL and OLF, and we describe the surgical approach, with a focus on technical nuances and strategies to avoid complications.

Conclusion

Careful presurgical planning and microsurgery are fundamental in achieving a satisfactory spinal cord decompression. IONM, endoscopy-assisted microsurgery and intraoperative navigation can enhance the safety of surgery and the extent of safe surgical decompression.

SUBMITTER: Baram A

PROVIDER: S-EPMC8212895 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

A rare case of giant calcified thoracic disc herniation, OPLL and OLF: how I do it.

Baram Ali A De Robertis Mario M Costa Francesco F

Acta neurochirurgica 20210618 9

<h4>Background</h4>Thoracic myelopathy can have different aetiologies. Based on the location and on the nature of spinal cord compression, different surgical approaches may be indicated.<h4>Method</h4>We present a rare case of thoracic myelopathy caused by the coexistence of a giant disc herniation, OPLL and OLF, and we describe the surgical approach, with a focus on technical nuances and strategies to avoid complications.<h4>Conclusion</h4>Careful presurgical planning and microsurgery are funda ...[more]

PMID: 34145501

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Project description:BACKGROUND:There is some limited evidence for the presence of viruses in herniated disc material including a previous case series that claimed to provide "unequivocal evidence of the presence of herpes virus DNA in intervertebral disc specimens of patients with lumbar disc herniation suggesting the potential role of herpes viruses as a contributing factor to the pathogenesis of degenerative disc disease". This study has not been replicated. The objective of our study was to determine if viruses were present in herniated disc fragments in participants with a prior history of back pain. METHODS:We recruited fifteen participants with a history of prior low-back pain prior to undergoing disc herniation surgery in the lumbar spine. Harvested disc samples were subject to next generation sequencing for detection of both RNA and DNA viral pathogens. Additionally, samples were analysed by a broadly reactive PCR targeting herpesviral DNA. Ethics approval was granted by the Human Research Ethics Committees of both Murdoch University, and St John of God Hospital, Western Australia. RESULTS:Of the fifteen research participants, 8 were female. Mean age was 49.4 years (SD 14.5 yrs) with a range of 24-70 years. All participants had prior back pain with mean time since first ever attack being 8.8 years (SD 8.8 yrs). No samples contained significant DNA sequences relating to known human viral agents. Inconsequential retroviral sequences were commonly found and were a mixture of putative animal and human retroviral protein coding segments. All samples were negative for herpesvirus DNA when analysed by pan-herpesvirus PCR. CONCLUSIONS:This study found no viral pathogens in any intervertebral disc fragments of patients who had previous back pain and underwent discectomy for disc herniation and thus it is unlikely that viruses are associated with disc herniation, however given the contradiction between key studies enhanced replication of this experiment is recommended.

Dataset Information

A rare case of giant calcified thoracic disc herniation, OPLL and OLF: how I do it.

Background

Method

Conclusion

Publications

A rare case of giant calcified thoracic disc herniation, OPLL and OLF: how I do it.

Similar Datasets

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