Inhibition of Exosome Release Sensitizes U937 Cells to PEGylated Liposomal Doxorubicin.

ABSTRACT:

Aims

Acute myeloblastic leukemia (AML) is the most common type of acute leukemia in adults. Despite numerous treatment strategies including chemotherapy and radiotherapy, a large number of patients do not respond to treatment and experience relapse. The main problem of these patients is the development of resistance to anti-cancer drugs. Therefore, any endeavor to reduce drug resistance in these patients is of high priority. In general, several mechanisms such as changes in drug metabolic pathways, drug inactivation, drug target alterations and reduced drug accumulation in the cells contribute to drug resistance of cancer cells. In this context, evidence suggests that exosomes could reduce drug resistance by removing drugs from their parent cells. In the present study, we aimed to

SUBMITTER: Hekmatirad S 

PROVIDER: S-EPMC8212994 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature