Agent-based modeling of the central amygdala and pain using cell-type specific physiological parameters.

ABSTRACT: The amygdala is a brain area involved in emotional regulation and pain. Over the course of the last 20 years, multiple researchers have studied sensory and motor connections within the amygdala in trying to understand the ultimate role of this structure in pain perception and descending control of pain. A number of investigators have been using cell-type specific manipulations to probe the underlying circuitry of the amygdala. As data have accumulated in this research space, we recognized a critical need for a single framework to integrate these data and evaluate emergent system-level responses. In this manuscript, we present an agent-based computational model of two distinct inhibitory neuron populations in the amygdala, those that express protein kinase C delta (PKCδ) and those that expr

SUBMITTER: Miller Neilan R 

PROVIDER: S-EPMC8213159 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature