Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing.

ABSTRACT: The scratch assay is an in vitro technique used to analyze cell migration, proliferation, and cell-to-cell interaction. In the assay, cells are grown to confluence and then 'scratched' with a sterile instrument. For the cells in the leading edge, the resulting polarity induces migration and proliferation in attempt to 'heal' the modeled wound. Keloid scars are known to have an accelerated wound closure phenotype in the scratch assay, representing an overactivation of wound healing. We performed a qualitative review of the recent literature searching for inhibitors of scratch assay activity that were already available in topical formulations under the hypothesis that such compounds may offer therapeutic potential in keloid treatment. Although several shortcomings in the scratch assay litera

SUBMITTER: Alishahedani ME 

PROVIDER: S-EPMC8213172 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature