Insulin resistance genetic risk score and burden of coronary artery disease in patients referred for coronary angiography.

ABSTRACT:

Aims

Insulin resistance associates with development of metabolic syndrome and risk of cardiovascular disease. The link between insulin resistance and cardiovascular disease is complex and multifactorial. Confirming the genetic link between insulin resistance, type 2 diabetes, and coronary artery disease, as well as the extent of coronary artery disease, is important and may provide better risk stratification for patients at risk. We investigated whether a genetic risk score of 53 single nucleotide polymorphisms known to be associated with insulin resistance phenotypes was associated with diabetes and burden of coronary artery disease.

Methods and results

We genotyped patients with a coronary angiography performed in the capital region of Denmark from 2010-2014 and constructe

SUBMITTER: Skals R 

PROVIDER: S-EPMC8213191 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature