Targeting Bruton's Tyrosine Kinase in Inflammatory and Autoimmune Pathologies.

ABSTRACT: Bruton's tyrosine kinase (BTK) was discovered due to its importance in B cell development, and it has a critical role in signal transduction downstream of the B cell receptor (BCR). Targeting of BTK with small molecule inhibitors has proven to be efficacious in several B cell malignancies. Interestingly, recent studies reveal increased BTK protein expression in circulating resting B cells of patients with systemic autoimmune disease (AID) compared with healthy controls. Moreover, BTK phosphorylation following BCR stimulation in vitro was enhanced. In addition to its role in BCR signaling, BTK is involved in many other pathways, including pattern recognition, Fc, and chemokine receptor signaling in B cells and myeloid cells. This broad involvement in several immunological pathways pr

SUBMITTER: Neys SFH 

PROVIDER: S-EPMC8213343 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature