High Glucose Activates YAP Signaling to Promote Vascular Inflammation.

ABSTRACT:

Background and aims

The YAP/TAZ signaling is known to regulate endothelial activation and vascular inflammation in response to shear stress. Moreover, YAP/TAZ signaling plays a role in the progression of cancers and renal damage associated with diabetes. However, whether YAP/TAZ signaling is also implicated in diabetes-associated vascular complications is not known.

Methods

The effect of high glucose on YAP/TAZ signaling was firstly evaluated in vitro on endothelial cells cultured under static conditions or subjected to shear stress (either laminar or oscillatory flow). The impact of diabetes on YAP/TAZ signaling was additionally assessed in vivo in db/db mice.

Results

In vitro, we found that YAP was dephosphorylated/activated by high gluco

SUBMITTER: Ortillon J 

PROVIDER: S-EPMC8213390 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature