Probiotic Streptococcus salivarius K12 Alleviates Radiation-Induced Oral Mucositis in Mice.

ABSTRACT:

Background

Oral mucositis is the most common oral complication of cancer patients receiving radiotherapy and/or chemotherapy, leading to poor quality of life. Limitations of the current interventions on radiation-induced oral mucositis (RIOM) urge the development of novel therapeutics. Here, we evaluated the treatment outcome of probiotic Streptococcus salivarius K12 on RIOM mice, and oral microbiota that is associated with the progress of RIOM was further investigated.

Methods

An experimental RIOM mouse model was established, and S. salivarius K12 was applied to the mouse oral cavity daily. Histological analyses were performed to evaluate the severity of oral mucositis and the treatment outcome of S. salivarius K12. The oral microbiota of mice was furth

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8213397 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature