Protective function and durability of mouse lymph node-resident memory CD8⁺ T cells.

ABSTRACT: Protective lung tissue-resident memory CD8⁺T cells (Trm) form after influenza A virus (IAV) infection. We show that IAV infection of mice generates CD69⁺CD103⁺and other memory CD8⁺T cell populations in lung-draining mediastinal lymph nodes (mLNs) from circulating naive or memory CD8⁺T cells. Repeated antigen exposure, mimicking seasonal IAV infections, generates quaternary memory (4M) CD8⁺T cells that protect mLN from viral infection better than 1M CD8⁺T cells. Better protection by 4M CD8⁺T cells associates with enhanced granzyme A/B expression and stable maintenance of mLN CD69⁺CD103⁺4M CD8⁺T cells, vs the steady decline of CD69⁺CD103⁺1M CD8^+<

SUBMITTER: Anthony SM 

PROVIDER: S-EPMC8213409 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature