Persistent premature mortality gap in dermatomyositis and polymyositis: a United Kingdom general population-based cohort study.

ABSTRACT:

Objective

DM and PM are associated with substantial morbidity and mortality. We aimed to examine recent trends.

Methods

Using The Health Improvement Network, we identified patients with incident DM/PM (defined by ≥1 Read diagnosis code) aged 18-89 years with ≥1 year of continuous enrolment prior to the cohort entry date and up to 10 comparators matched on age, sex and entry year. The cohort was divided in two based on the year of DM/PM diagnosis: the early cohort (1999-2006) and late cohort (2007-2014). We calculated multivariable hazard ratios (HR) for death using a Cox-proportional hazards model and multivariable rate differences (RD) using an additive hazard model.

Results

We identified 410 DM cases (mean age: 58 years, 66% female) and 407 PM cases (mean age: 59 ye

SUBMITTER: D'Silva KM 

PROVIDER: S-EPMC8213423 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature