Longitudinal changes in cerebral white matter microstructure in newly diagnosed systemic lupus erythematosus patients.

ABSTRACT:

Objectives

To evaluate longitudinal variations in diffusion tensor imaging (DTI) metrics of different white matter (WM) tracts of newly diagnosed SLE patients, and to assess whether DTI changes relate to changes in clinical characteristics over time.

Methods

A total of 17 newly diagnosed SLE patients (19-55 years) were assessed within 24 months from diagnosis with brain MRI (1.5 T Philips Achieva) at baseline, and after at least 12 months. Fractional anisotropy, mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity values were calculated in several normal-appearing WM tracts. Longitudinal variations in DTI metrics were analysed by repeated measures analysis of variance. DTI changes were separately assessed for 21 WM tracts. Associations between longitudinal al

SUBMITTER: Silvagni E 

PROVIDER: S-EPMC8213425 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature