Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis.

ABSTRACT:

Objectives

The aetiology of primary chronic pain syndromes (CPS) is highly disputed. We performed a systematic review and meta-analysis aiming to assess differences in circulating cytokine levels in patients with diffuse CPS (fibromyalgia) vs healthy controls (HC).

Methods

Human studies published in English from the PubMed, MEDLINE/Scopus and Cochrane databases were systematically searched from inception up to January 2020. We included full text cross-sectional or longitudinal studies with baseline cytokine measurements, reporting differences in circulating cytokine levels between fibromyalgia patients and HC. Random-effects meta-analysis models were used to report pooled effects and 95% CIs. This study is registered with PROSPERO (CRD42020193774).

Results

Our initial

SUBMITTER: O'Mahony LF 

PROVIDER: S-EPMC8213433 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature