Risk of precancerous cervical lesions in women using a hormone-containing intrauterine device and other contraceptives: a register-based cohort study from Denmark.

ABSTRACT:

Study question

Is the risk of high-grade precancerous cervical lesions and/or is the risk of lesion progression increased in users of a hormone-containing intrauterine device (HIUD) compared with users of other contraceptive methods.

Summary answer

Women starting use of HIUD had the same subsequent risk of cervical intraepithelial neoplasia 3+ (CIN3+) as copper IUD (CIUD) users, and both groups tended to have lower risks than oral contraceptives (OC) users.

What is known already

HIUDs may cause inflammatory and immunosuppressive changes that may potentially affect the risk of persistent human papillomavirus infection and precancerous cervical lesions.

Study design, size, duration

A Danish population-based cohort study was conducted using register data from 2008

SUBMITTER: Skorstengaard M 

PROVIDER: S-EPMC8213448 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature