Multi-dimensional and longitudinal systems profiling reveals predictive pattern of severe COVID-19.

ABSTRACT: COVID-19 is a respiratory tract infection that can affect multiple organ systems. Predicting the severity and clinical outcome of individual patients is a major unmet clinical need that remains challenging due to intra- and inter-patient variability. Here, we longitudinally profiled and integrated more than 150 clinical, laboratory, and immunological parameters of 173 patients with mild to fatal COVID-19. Using systems biology, we detected progressive dysregulation of multiple parameters indicative of organ damage that correlated with disease severity, particularly affecting kidneys, hepatobiliary system, and immune landscape. By performing unsupervised clustering and trajectory analysis, we identified T and B cell depletion as early indicators of a complicated disease course. In addition,

SUBMITTER: Woo MS 

PROVIDER: S-EPMC8213514 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature