Indices of peripheral leukocytes predict longer overall survival in breast cancer patients on eribulin in Japan.

ABSTRACT:

Background

It was reported that eribulin regulates the tumor microenvironment, including the immune system, by inducing vascular remodeling. Lymphocyte counts are a critical index of immune response in patients. The non-Asian, global EMBRACE study has suggested that baseline absolute lymphocyte count (ALC) may be a predictor of the survival benefit of eribulin in breast cancer patients. We examined whether the baseline ALC is a potential predictor of overall survival (OS) in Japanese patients with HER2-negative advanced breast cancer treated with eribulin.

Methods

This was a post hoc analysis of data from a post-marketing observational study of eribulin in Japan. The OS by baseline ALC was estimated using the Kaplan-Meier method, with the cut-off value of 1500/μL for ALC. Th

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC8213560 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature