Mendelian randomization suggests that head circumference, but not birth weight and length, associates with intelligence.

ABSTRACT:

Introduction

Birth parameters have long been reported to have a role in human intelligence. However, the causalities reported in previous observational studies were controversial. Our study aims to provide an unbiased investigation of the causal associations between birth parameters and human intelligence using the Mendelian randomization (MR) approach.

Methods

Genetic instrumental variables for MR analyses were extracted from large genome-wide association studies of infant head circumference (N = 10,768), birth length (N = 28,489), and birth weight (N = 321,223). Data for intelligence were obtained from a meta-analysis of genome-wide association studies of 269,867 individuals of the European ancestry. Primary MR analysis was performed using the standard inverse-variance wei

SUBMITTER: Qian L 

PROVIDER: S-EPMC8213647 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature