Ontology highlight
ABSTRACT:
SUBMITTER: Miyauchi K
PROVIDER: S-EPMC8213721 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Miyauchi Kosuke K Adachi Yu Y Tonouchi Keisuke K Yajima Taiki T Harada Yasuyo Y Fukuyama Hidehiro H Deno Senka S Iwakura Yoichiro Y Yoshimura Akihiko A Hasegawa Hideki H Yugi Katsuyuki K Fujii Shin-Ichiro SI Ohara Osamu O Takahashi Yoshimasa Y Kubo Masato M
Nature communications 20210618 1
Influenza viruses are a major public health problem. Vaccines are the best available countermeasure to induce effective immunity against infection with seasonal influenza viruses; however, the breadth of antibody responses in infection versus vaccination is quite different. Here, we show that nasal infection controls two sequential processes to induce neutralizing IgG antibodies recognizing the hemagglutinin (HA) of heterotypic strains. The first is viral replication in the lung, which facilitat ...[more]