Messenger RNA expressing PfCSP induces functional, protective immune responses against malaria in mice.

ABSTRACT: Human malaria affects the vast majority of the world's population with the Plasmodium falciparum species causing the highest rates of morbidity and mortality. With no licensed vaccine and leading candidates achieving suboptimal protection in the field, the need for an effective immunoprophylactic option continues to motivate the malaria research community to explore alternative technologies. Recent advances in the mRNA discipline have elevated the long-neglected platform to the forefront of infectious disease research. As the immunodominant coat protein of the invasive stage of the malaria parasite, circumsporozoite protein (PfCSP) was selected as the antigen of choice to assess the immunogenic and protective potential of an mRNA malaria vaccine. In mammalian cell transfection experiments,

SUBMITTER: Mallory KL 

PROVIDER: S-EPMC8213722 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature