Electrically conductive 3D printed Ti₃C₂T_x MXene-PEG composite constructs for cardiac tissue engineering.

ABSTRACT: Tissue engineered cardiac patches have great potential as a therapeutic treatment for myocardial infarction (MI). However, for successful integration with the native tissue and proper function of the cells comprising the patch, it is crucial for these patches to mimic the ordered structure of the native extracellular matrix and the electroconductivity of the human heart. In this study, a new composite construct that can provide both conductive and topographical cues for human induced pluripotent stem cell derived cardiomyocytes (iCMs) is developed for cardiac tissue engineering applications. The constructs are fabricated by 3D printing conductive titanium carbide (Ti₃C₂T_x) MXene in pre-designed patterns on polyethylene glycol (PEG) hydrogels, using aerosol

SUBMITTER: Basara G 

PROVIDER: S-EPMC8213874 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature