Safety and efficacy of intravenous thrombolytic treatment in wake-up stroke: Experiences from a single center.

ABSTRACT:

Objectives

Wake-up stroke is an important clinical problem that may account for a quarter of all ischemic strokes. This study aimed to establish the safety and efficacy of intravenous thrombolytic treatment of wake-up strokes by comparing it to the standard thrombolysis treatment in strokes with clear onsets and wake-up strokes that did not receive reperfusion therapy.

Methods

This retrospective study enrolled 95 patients with ischemic strokes who underwent thrombolytic treatment with alteplase, including nine patients with wake-up strokes. The safety profile (mortality and intracranial bleeding) and efficacy (clinical and functional outcomes on admission, discharge, and 90 days after stroke onset) were evaluated.

Results

When assessed using the modified Rankin scale

SUBMITTER: Wisniewski A 

PROVIDER: S-EPMC8213934 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature