Chronic Antibiotic-Refractory Pouchitis: Management Challenges.

ABSTRACT:

Background

Pouchitis is the most common long-term complication in patients with ulcerative colitis who underwent restorative proctocolectomy with ileal pouch-anal anastomosis. The incidence of acute pouchitis is 20% after 1 year and up to 40% after 5 years. Chronic antibiotic-refractory pouchitis develops in approximately 10% of patients.

Aim

To present a narrative review of published literature regarding the management of chronic antibiotic-refractory pouchitis.

Methods

Current relevant literature was summarized and critically evaluated.

Results

Clear definitions should be used to classify pouchitis into acute versus chronic, and responsive versus dependent versus refractory to antibiotics. Before treatment is started for chronic antibiotic-refractory pouchiti

SUBMITTER: Outtier A 

PROVIDER: S-EPMC8213947 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature