[Association between maternal reduced folate carrier gene polymorphisms and congenital heart disease in offspring: a case-control study].

ABSTRACT:

Objective

To study the association between maternal reduced folate carrier (RFC) gene polymorphisms and congenital heart disease (CHD) in offspring.

Methods

A hospital-based case-control study was conducted. The mothers of 683 infants with CHD who attended the Department of Cardiothoracic Surgery, Hunan Children's Hospital, from November 2017 to March 2020 were enrolled as the case group. The mothers of 740 healthy infants without any deformity who attended the hospital during the same period of time were enrolled as the control group. A questionnaire survey was performed to collect the exposure data of subjects. Venous blood samples of 5 mL were collected from the mothers for genetic polymorphism detection. A multivariate logistic regression analysis was used to eval

SUBMITTER: Qin JB 

PROVIDER: S-EPMC8214001 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature