Novel RNAi-Based Therapies for Atherosclerosis.

ABSTRACT:

Purpose of review

Atherosclerosis, defined by inflammation and accumulation of cholesterol, extracellular matrix, and cell debris into the arteries is a common factor behind cardiovascular diseases (CVD), such as coronary artery disease, peripheral artery disease, and stroke. In this review, we discuss and describe novel RNA interference (RNAi)-based therapies in clinical trials and on the market.

Recent findings

The first RNAi-based therapies have entered clinical use for the control of atherosclerosis risk factors, i.e., blood cholesterol levels. The most advanced treatment is silencing of proprotein convertase subtilisin/kexin type 9 (PCSK9) with a drug called inclisiran, which has been approved for the treatment of hypercholesterolemia in late 2020, and results in a robu

SUBMITTER: Ruotsalainen AK 

PROVIDER: S-EPMC8214045 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature