Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate.

ABSTRACT: A wide homology between human and macaque striatum is often assumed as in both the striatum is involved in cognition, emotion and executive functions. However, differences in functional and structural organization between human and macaque striatum may reveal evolutionary divergence and shed light on human vulnerability to neuropsychiatric diseases. For instance, dopaminergic dysfunction of the human striatum is considered to be a pathophysiological underpinning of different disorders, such as Parkinson's disease (PD) and schizophrenia (SCZ). Previous investigations have found a wide similarity in structural connectivity of the striatum between human and macaque, leaving the cross-species comparison of its functional organization unknown. In this study, resting-state functional connectivit

SUBMITTER: Liu X 

PROVIDER: S-EPMC8214073 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature