Clinicopathological characteristics of androgen receptor splicing variant 7 (AR-V7) expression in patients with castration resistant prostate cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

 Studies have shown that AR-V7 may be correlated with the poor prognosis of castration resistant prostate cancer (CRPC), however, clinicopathological characteristics of AR-V7 have not been fully elucidated.

Objective

This study aimed at evaluating the clinicopathological features of AR-V7 in CRPC patients.

Materials and methods

To evaluate the clinicopathological features of AR-V7 in CRPC patients. A search of PubMed, Embase, and Web of Science was performed using the keywords prostate cancer, prostate tumor, prostate neoplasm, prostate carcinoma, AR-V7, AR3, androgen receptor splicing variant-7, or androgen receptor-3. Twenty-four trials published by February 2020 were included in this study.

Results

The proportion of Gleason score ≥ 8 was found to

SUBMITTER: Li Q 

PROVIDER: S-EPMC8214144 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature