Positive renal familial history in IgA nephropathy is associated with worse renal outcomes: a single-center longitudinal study.

ABSTRACT:

Background

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Although most IgAN cases are sporadic, few show a familial aggregation. However, the prevalence and prognosis of IgAN individuals with positive familial history (FH) of renal disorders remains uncertain. To address these issues, we conducted a longitudinal observational study on a single-institution cohort of patients with biopsy-proven IgAN.

Methods

A total of 467 IgAN patients who underwent renal biopsy during 1994 to 2019 were ascertained to have positive- or negative-FH by history taking and were followed for an average of 8.9 years. We compared the clinical and pathological features of the two subgroups. The primary outcome, a composite of a hard endpoint (end-stage renal disease

SUBMITTER: Sato Y 

PROVIDER: S-EPMC8214250 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature