Taurine promotes the production of CD4⁺CD25⁺FOXP3⁺ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.

ABSTRACT:

Background

Allergic rhinitis (AR) is one of the most widespread immune conditions worldwide. However, common treatments often present with significant side effects or are cost-prohibitive for much of the population. A plethora of treatments have been used for the treatment of AR including antihistamines, steroids, and immune modulators. Among the treatments which have shown potential for efficacy in treating AR with a minimum of side effects but remains understudied is the conditionally essential amino acid taurine. Taurine has been previously shown to reduce AR symptoms. Here, we examine the role of taurine in modulating T regulatory cells, modulating the cytokine response in AR, and restoring healthy nasal mucosa.

Methods

Blood samples from 20 healthy donors and 20 AR pati

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8214264 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature